Recently Published Articles
Evaluation of Direct Cost of Adverse Drug Reactions to Highly Active Antiretroviral Therapy in Indian Human Immunodeficiency Virus Positive Patients
Citation:
Vasudeva Guddattu, Noorunnisa, Sudha Vidyasagar, Radhakrishnan Rajesh,Danturulu M. Varma; Evaluation Of Direct Cost Of Adverse Drug Reactions To Highly Active Antiretroviral Therapy In Indian Human Immunodeficiency Virus Positive Patients.(2012)Open Access Pub. JCRHAP,Vol 1:Issue 1,pg no.12-22. DOI: 10.14302/issn.2324-7339.jcrhap-12-71
Abstract:
In India, interruptions to highly active antiretroviral therapy (HAART) are due to adverse drug reactions (ADRs) and no reports on the direct cost incurred in the management of ADRs to HAART are available. There is a need to study direct cost incurred with ADRs to HAART to explore the high economic cost burden imposed by ADRs to HAART in HIV/AIDS patients. This study was aimed to evaluate the direct cost incurred in the management of ADRs to HAART in Indian HIV positive patients. This prospective study was conducted at a Medicine department in a South Indian tertiary care teaching hospitals were ADRs reporting system exist. HIV-positive hospitalized in-patients were identified and intensively monitored for ADRs to HAART. The World Health Organization (WHO) probability scale was used for causality assessment of ADRs. Modified Hart wig and Siegel scale was used for severity assessment of ADRs.Pearson chi-square test identified association of mean direct cost between...
Dual Choice for Dual Target Anti-HIV Therapy
Abstract:
This editorial discusses combination strategies that concurrently target viral replication and host factors in HIV therapy. It surveys candidate mechanisms, potential benefits, and safety considerations, advocating rigorous trials to balance efficacy with tolerability in diverse patient populations.
Editorial for Journal of Proteomics and Genomics Research
Abstract:
An editorial announcing the journal’s launch sets expectations for data standards, reproducibility, and integrative omics studies with clinical relevance.
Optimization and ZSPORE Analysis of Affinity Purification Coupled with Tandem Mass Spectrometry in Mammalian Cells
Abstract:
Defining protein-protein interactions is essential for understanding the mechanisms by which cells regulate basic functions, such as metabolism, transcription, and signal transduction. Affinity purification followed by tandem mass spectrometry (AP-MS) has application for discovery of new interactors regulating various cellular processes. Here we optimize the purification method for AP-MS and develop a simplified unbiased analytical tool, Z-score plus prey occurrence and reproducibility (ZSPORE) for data analysis. Using this pipeline we achieve a higher efficiency of AP-MS and enhanced identification of high confidence interacting proteins (HCIP) in mammalian cells. When applied to analysis of the innate immune interactome, these methods enhanced HCIP identification. In addition, we investigated the GRB2 complex, which is associated with signal transduction and cell growth. Twenty-four known GRB2 interacting proteins were identified plus 26 new GRB2 binding partner...
Eukaryotic Signature Proteins
Abstract:
Eukaryotic Signature Proteins (ESPs) are proteins that delineate the eukaryotes from the archaea and bacteria. They have no recognisable homologues in any prokaryotic genome, but their homologues are present in all main branches of eukaryotes. ESPs are thus likely to have descended from ancient proteins that have existed since the first eukaryotic cell. The last dataset of ESPs was calculated more than a decade ago, thus with advances in technology and the rapid completion of many evolutionary important genomes, this dataset required recalculating. This study recalculated the Giardia lamblia ESP dataset and provides a procedure to calculate signature proteins beginning with any species. The G. lamblia ESP dataset contained a range of proteins including many associated with the membrane, cytoskeleton, nucleus and protein synthesis. ESP datasets have implications on current models of eukaryotic evolution, having high importance in phylogenetic analysis due to ESPs�...
Lung Cancer and Isolated Adrenal Metastases: Different Disease?
Abstract:
Distant metastases generally indicate disseminated disease and the standard treatment for these patients is palliative chemotherapy. Retrospective series showed that selected patients with metastatic lung cancer and a solitary extrathoracic disease could be effectively treated with curative intention by resection of both primary tumor and the single site of metastatic disease. According to current data, adrenalectomy might be considered as an alternative option for patients with isolated adrenal metastases. Significant morbidity and mortality may be happened by these procedures, and a cautious analysis of pros and cons should be discussed with the patient. We present a review of the literature and updated recommendations focusing lung cancer with solitary adrenal metastasis.
The Evaluation of Forage Silage Related Traits Between Maize and Hybrid Giant Napier (Pennisetum Hydridum)
Abstract:
Selecting elite silage specific variety was important for modern animal husbandry development and agricultural production. In this paper, six forage quality related physiology traits were evaluated by using chemical detection method, the difference between maize silage and hybrid giant napier (