Aims & Scope

International Journal of Bone and Mineral Metabolism (IJBM) publishes original research and reviews on the molecular, cellular, and clinical aspects of bone biology, mineral metabolism, and metabolic bone diseases, bridging basic science with translational applications.

Bone Metabolism Mineral Homeostasis Metabolic Bone Diseases Calcium & Phosphate Vitamin D

⚠ Scope Boundary: We do NOT consider manuscripts focused primarily on hematological malignancies, general orthopedic surgery techniques, or sports medicine without direct relevance to bone/mineral metabolism.

Research Scope

Tier 1: Core Research Domains

Bone Biology & Metabolism

Osteoblast and osteoclast biology
Bone remodeling and turnover mechanisms
Bone matrix composition and mineralization
Bone formation and resorption pathways
Cellular signaling in bone homeostasis
Bone quality and microarchitecture

Typical fit: "Molecular mechanisms of osteoblast differentiation regulated by Wnt/β-catenin signaling in osteoporosis"

Mineral Metabolism

Calcium and phosphate homeostasis
Vitamin D metabolism and signaling
Parathyroid hormone (PTH) regulation
FGF23-Klotho axis
Calcitonin and bone-kidney interactions
Magnesium metabolism in bone health

Typical fit: "FGF23 regulation of phosphate homeostasis and its implications for chronic kidney disease-mineral bone disorder"

Metabolic Bone Diseases

Osteoporosis: pathophysiology and treatment
Osteomalacia and rickets
Paget's disease of bone
Osteogenesis imperfecta
Renal osteodystrophy
Hypophosphatasia and mineralization disorders

Typical fit: "Long-term efficacy of bisphosphonate therapy in postmenopausal osteoporosis: a 10-year prospective study"

Endocrine Regulation of Bone

Sex hormones and bone metabolism
Thyroid hormones in skeletal development
Growth hormone-IGF-1 axis
Glucocorticoid-induced bone disease
Insulin and bone metabolism
Adipokines and bone health

Typical fit: "Estrogen receptor signaling in bone: implications for postmenopausal osteoporosis prevention"

Tier 2: Secondary Focus Areas

Bone Biomarkers

Biochemical markers of bone turnover (CTX, P1NP, bone-specific alkaline phosphatase) for diagnosis and monitoring of metabolic bone diseases.

Imaging & Diagnostics

DXA, QCT, HR-pQCT, and novel imaging modalities for assessing bone mineral density, microarchitecture, and fracture risk.

Pharmacological Interventions

Antiresorptive agents (bisphosphonates, denosumab), anabolic therapies (teriparatide, romosozumab), and emerging therapeutics for bone diseases.

Genetics & Epigenetics

Genetic determinants of bone mass, monogenic bone disorders, genome-wide association studies, and epigenetic regulation of bone metabolism.

Bone-Muscle Interactions

Sarcopenia, osteosarcopenia, myokines, and the musculoskeletal unit in aging and metabolic disease.

Computational & AI Approaches

Machine learning for fracture risk prediction, bone quality assessment, and personalized treatment strategies in metabolic bone diseases.

Tier 3: Emerging & Selective Areas

Bone mechanobiology and mechanical loading responses
Bone marrow adiposity and metabolic dysfunction
Gut microbiome-bone axis
Senescence and aging in bone metabolism
Bone metastases: metabolic aspects (not primary oncology)
Nutritional interventions in bone health
Exercise physiology and bone adaptation
Circadian rhythms in bone remodeling

ⓘ Editorial Note: Manuscripts in emerging areas undergo additional editorial review to ensure strong relevance to bone and mineral metabolism. Studies must demonstrate clear mechanistic or translational connections to core scope.

Out of Scope

Hematological malignancies: Leukemia, lymphoma, multiple myeloma (unless focused on bone metabolism complications such as myeloma bone disease)
General orthopedic surgery: Arthroplasty, arthroscopy, surgical techniques without direct bone metabolism relevance
Sports injuries & rehabilitation: Ligament tears, muscle strains, general physiotherapy (unless addressing bone stress injuries or metabolic aspects)
Primary hematology: Anemia, hemophilia, thrombosis, neutropenia without bone marrow or skeletal involvement
General rheumatology: Autoimmune arthritis, systemic lupus (unless specifically addressing bone loss mechanisms)

Article Types & Priorities

Priority 1 Fast-Track Review

Original Research Articles
Systematic Reviews & Meta-Analyses
Methods & Protocols
Clinical Trials

Priority 2 Standard Review

Short Communications
Data Notes
Perspectives & Commentaries
Review Articles

Selective Rarely Considered

Case Reports (exceptional cases only)
Opinion Pieces
Letters to the Editor

Editorial Standards & Requirements

Reporting Guidelines

CONSORT (trials), STROBE (observational), PRISMA (reviews), ARRIVE (animal studies), STARD (diagnostics)

Data Transparency

Raw data deposition in public repositories encouraged; data availability statements required

Ethics Approval

IRB/IACUC approval mandatory for human/animal studies; informed consent documentation required

Preprint Policy

Preprints accepted; must be disclosed upon submission; does not affect consideration

Conflict of Interest

Full disclosure required; financial relationships with bone therapeutics companies must be declared

Statistical Rigor

Power calculations, appropriate statistical tests, correction for multiple comparisons required

Publication Metrics

21 Days to First Decision

32% Acceptance Rate

45 Days to Publication

Open Access Model

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International Journal of Bone and Mineral Metabolism

International Journal of Bone and Mineral Metabolism – Aim And Scope